Cytotoxic Sterols from Philippine Mushrooms

New sterols and triterpenoids from four edible mushrooms.

Four edible mushrooms, Panellus serotinus, Lepista nuda, Tricholoma matsutake and Naematoloma sublateritium, have been investigated chemically. Two new sterols, 5alpha,9alpha-epidioxy-(22E)-ergosta-7,22-diene-3beta,6alpha-diol (1) and 5alpha,9alpha-epidioxy-(22E)-ergosta-7,22-diene-3beta,6beta-diol (2), have been isolated from Panellus serotinus. Compound 2 was also isolated from Lepista nuda. ...

New Cytotoxic Oxygenated Sterols from the Marine Bryozoan Cryptosula pallasiana

Six new sterols (1-6), together with seven known sterols (7-13), were isolated from the CCl(4) extract of the marine bryozoan Cryptosula pallasiana, four (3-6) of which have already been reported as synthetic sterols. This is the first time that these compounds (3-6) are reported as natural sterols. The structures of the new compounds were determined on the basis of the extensive spectroscopic ...

Lissoclinotoxins E and F, novel cytotoxic alkaloids from a Philippine didemnid ascidian Author

Bioassay-guided fractionation of the MeOH extract from a Philippine didemnid ascidian resulted in the isolation of two new dimeric alkaloids, lissoclinotoxins E (1) and F (2). The polysulfide structures for compounds 1 and 2 were determined by interpretation of spectroscopic data and chemical degradation. Computational chemistry studies suggested that the N-alkyl chains about the tricyclic syst...

Cytotoxic bromoindole derivatives and terpenes from the Philippine marine sponge Smenospongia sp.

A detailed chemical analysis of a Philippine marine sponge Smenospongia sp. has been performed. This study yielded four new metabolites, 5-bromo-L-tryptophan (1), 5-bromoabrine (2), 5,6-dibromoabrine (3) and 5-bromoindole-3-acetic acid (4). The pyrroloiminoquinone alkaloid, makaluvamine O (5) as well as 5,6-dibromotryptamine (6), aureol (7) and furospinulosin 1 (8) were also isolated. Although ...

Nutriceuticals from Mushrooms